Hormone-related depression, if experienced earlier in life, may return during menopause, Dr. Catellani says. St. John's wort, long recognized for its ability to fight "melancholy," has been shown to be as effective as some prescription antidepressants for mild to moderate depression. "It's less likely than prescription antidepressants to cause side effects, such as fatigue, loss of sexual interest, or dry mouth," she explains.
The dosage used in most clinical trials was 300 milligrams in capsule form, three times a day, of an extract containing 0.3 percent hypericin, one of the active ingredients in St. John's wort. And you may need to use it regularly for 2 to 3 weeks before you see an effect. If symptoms persist, seek immediate help from a qualified mental health professional.